1990-08-01 · View protein in InterPro IPR001304, C-type_lectin-like IPR016186, C-type_lectin-like/link_sf IPR018378, C-type_lectin_CS IPR016187, CTDL_fold IPR000742, EGF-like_dom IPR033991, Selectin_CTLD IPR002396, Selectin_superfamily IPR035976, Sushi/SCR/CCP_sf IPR000436, Sushi_SCR_CCP_dom: Pfam i

Members of the selectin family, E-selectin (endothelial), L-selectin (leukocyte) and P-selectin (platelet), all of which bind to fucosylated carbohydrates [1].

They have been extensively studied due to their role in the inflammatory response and their potential use as therapeutic targets. E-selectin, also known as CD62 antigen-like family member E, endothelial-leukocyte adhesion molecule 1, or leukocyte-endothelial cell adhesion molecule 2, is a selectin cell adhesion molecule expressed only on endothelial cells activated by cytokines. Like other selectins, it plays an important part in inflammation. In humans, E-selectin is encoded by the SELE gene. 1997-02-01 · Recently, several groups have reported that PSGL-1 might also serve as a ligand for E-selectin. Differential posttranslational modifications of PSGL-1 may determine whether it can interact with either P- or E-selectin or both. To determine whether PSGL-1 is essential for adhesion to P- or E-selectin, we have constructed and analyzed a panel of stably transfected K562 cells.

FAB6169F. 2 Citations. Clonality: Monoclonal. Host: Mouse IgG1 Clone #BBIG-E6 (13D5) Applications: Flow. 1 Image.

E and P-selectin are produced by the endothelial cells that line the vessel walls of the circulatory system. They function How it works. The role of E and P- selectin begins with the inflammatory immune response. E-selectin versus

Compatible samples: cell culture supernates, serum and Hrsg . von P. Langenscheidt . Wulffen , E. , Psychologie des Verbrechers . 9 : e éd .

Selectins. Selektiner. Engelsk definition. Transmembrane proteins consisting of a lectin-like domain, an epidermal growth factor-like domain, and a variable

Both E-and P-selectins are expressed on human arterial luminal endothelial cells of atherosclerotic plaques (195, 196), and mouse studies have shown that E-selectin and/or P-selectin deficiency substantially reduces the formation of atherosclerotic plaques, suggesting an overlapping function of these two selectins in the development of atherosclerotic lesions (197, 198). Combined, E‐selectin and P‐selectin mAb treatment inhibited T cell accumulation in all four types of reactions, and significantly more than E‐selectin blockade alone in migration to Con A. Results in E‐selectin‐ and P‐selectin‐deficient mice confirmed these observations, and demonstrated strain‐dependent differences in the contributions of the two selectins. 2018-08-02 · Moreover, whereas E-selectin is derived solely from endothelial cells, the other CAMs are derived from multiple sources such as platelets (P-selectin), leukocytes (ICAM-1) and cell types of non-vascular origin (VCAM-1), which may explain the strong association of E-selectin with aortic PWV . P-selectin–deficient (Selp −/−) mice bred with apolipoprotein E–deficient (Apoe −/−) mice or with low-density lipoprotein (LDL) receptor–deficient (Ldlr −/−) mice develop smaller atherosclerotic lesions than control mice. 15 – 18 Bone marrow transplantation experiments suggest that P-selectin on nonhematopoietic presumably endothelial cells contributes more to atherosclerosis than P-selectin on hematopoietic cells. 19 However, infusion of activated platelets initiates The identity of the amplified baboon cDNA fragments was confirmed by DNA sequencing; the nucleotide sequence of the baboon P-selectin cDNA fragment was 99% identical to that of the human P-selectin cDNA, and the nucleotide sequence of the baboon E-selectin cDNA was 97% identical to that of the human E-selectin cDNA.

P-selectin acts as a receptor that supports binding of leukocytes to activated platelets and endothelium. P-selectin-mediated adhesive interactions operate in conjunction with cell-cell interactions directed by related molecules and are likely to be important in both hemostatic and inflammatory processes.
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(J) SB431542 or DMSO was injected into the wound edges of mice (5 versus 5) The expression of pri-miR-132 positively correlated (R = 0.59, P = 0.004) with such as vascular cell adhesion protein 1 (VCAM1) and E-selectin (SELE) (18). P <0, 05, ** P <0, 01 och *** P <0, 001; NS, obetydlig. Den högre nivån av ICAM-1 relativt E-selectin och VCAM-1 i icke-aktiverade Histograms of per cent max versus fluorescence (FL1-4) were plotted on the y and x axis, respectively.

Format: 96-well plate with removable strips.
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2018-08-02 · Moreover, whereas E-selectin is derived solely from endothelial cells, the other CAMs are derived from multiple sources such as platelets (P-selectin), leukocytes (ICAM-1) and cell types of non-vascular origin (VCAM-1), which may explain the strong association of E-selectin with aortic PWV .

P-selectin, L-selectin, and alpha 4 integrin have distinct roles in eosinophil tethering and arrest on vascular endothelial cells under physiological flow conditions. Kitayama J , Fuhlbrigge RC , Puri KD , Springer TA P-selectin (CD62, GMP-140, PADGEM) belongs to the selectin family of adhesion molecules.

While the current study examines binding to P-selectin versus a control substrate with no target-ligand, it is possible to immobilize another ligand like E-selectin in

2021. Open Access icon e-selectin, and endostatin in an exploratory study in men with prostate cancer healthy subjects after intake of whole-grain rye porridges versus refined wheat bread. av J Hirsh · 2001 · Citerat av 600 — Google Scholar; 11 Falk E. Unstable angina with fatal outcome: dynamic Subcutaneous vs intravenous heparin in the treatment of deep venous Plasma P-selectin is increased in thrombotic consumptive platelet disorders. Detect Mouse P Selectin/SELP with <5pg/ml sensitivity. Format: 96-well plate with removable strips. Compatible samples: cell culture supernates, serum and Hrsg . von P. Langenscheidt .

Transmembrane proteins consisting of a lectin-like domain, an epidermal growth factor-like domain, and a variable Beläggning av mikroflödeskanal med fibronektin eller P-/E-selectin var splittrad (varje färg representerar en annan cell, se exempelvis celler af vs gl i figur 4B). P-selectin mediates neutrophil rolling and recruitment in acute pancreatitis 30·00) versus 1·55 (0·60-15·70) μg/l; P = 0·017), neutrophil accumulation (4·00 (0·75-4·00) versus 0·63 (0-3·25); P = 0·002) and tissue damage, E-ISSN: 13652168.